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Safe, Underground, Impreginable Vaults.  These Vaults were made to save people when the bombs fell.  At least, they were meant to save people at first....

The Vaults, ended up becoming government experiments.  Like, some there is One man, while all the other residents were women.  There is one that had many people inside, all with very different ideas (Vault 15 (a vault in Fallout and Fallout 2)).  Vault-Tec, the company who made the vaults, didn't want this, but the Enclave forced them.  So there was the great Vault Experiment.